• Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons 

      Østnes Hansen, Kine; Hansen, Ida Kristine Østnes; Richard, Céline Sarah Marine; Jenssen, Marte; Andersen, Jeanette Hammer; Hansen, Espen Holst (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-02-21)
      Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan <i>Securiflustra securifrons</i> was found to be active against ...
    • Bioactivity of Serratiochelin A, a Siderophore Isolated from a Co-Culture of Serratia sp. and Shewanella sp. 

      Schneider, Yannik Karl-Heinz; Jenssen, Marte; Isaksson, Johan; Østnes Hansen, Kine; Andersen, Jeanette Hammer; Hansen, Espen (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-07-14)
      Siderophores are compounds with high affinity for ferric iron. Bacteria produce these compounds to acquire iron in iron-limiting conditions. Iron is one of the most abundant metals on earth, and its presence is necessary for many vital life processes. Bacteria from the genus <i>Serratia</i> contribute to the iron respiration in their environments, and previously several siderophores have been isolated ...
    • Bioprospecting of marine microorganisms for the discovery of antibacterial compounds - Isolation, structure elucidation and bioactivity assessment of marine microbial natural products 

      Jenssen, Marte (Doctoral thesis; Doktorgradsavhandling, 2022-04-27)
      <p>Infectious diseases have been a problem for humans since the beginning of human existence. The “golden age” of antibiotics started at the end of the 1920s, with the discovery of penicillin by Sir Alexander Fleming. This was followed by the discovery of several life-saving antibiotics. The number of new marketed antibiotics has declined, and most pharmaceutical companies are no longer working in ...
    • Chlovalicin B, a Chlorinated Sesquiterpene Isolated from the Marine Mushroom Digitatispora marina 

      Jenssen, Marte; Kristoffersen, Venke; Motiram-Corral, Kumar; Isaksson, Johan; Rämä, Teppo; Andersen, Jeanette Hammer; Hansen, Espen; Østnes Hansen, Kine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-13)
      As part of our search for bioactive metabolites from understudied marine microorganisms, the new chlorinated metabolite chlovalicin B (1) was isolated from liquid cultures of the marine basidiomycete Digitatispora marina, which was collected and isolated from driftwood found at Vannøya, Norway. The structure of the novel compound was elucidated by spectroscopic methods including 1D and 2D NMR and ...
    • Exploring the potential of two arctic marine bacteria for the production of bioactive metabolites 

      Jenssen, Marte (Master thesis; Mastergradsoppgave, 2017-05-15)
      The number of compounds being isolated from the marine environment is increasing, and there is a great potential for discovering new marine derived drug candidates. Improved collection techniques has strengthened bioprospecting on a wider diversity of marine microorganisms. The focus on microorganisms has led to the realisation that many of the natural products originally isolated from macroorganisms, ...
    • Identification of New Purpuroine Analogues from the Arctic Echinodermata Pteraster militaris That Inhibit FLT3-ITD+ AML Cell Lines 

      Østnes Hansen, Kine; Hansen, Ida Kristine Østnes; Ullsten-Wahlund, Sara; Jenssen, Marte; Isaksson, Johan Mattias; Li, Chun; Schneider, Yannik K.-H. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-13)
      Isolation of bioactive products from the marine environment is considered a very promising approach to identify new compounds that can be used for further drug development. In this work we have isolated three new compounds from the purpuroine family by mass-guided preparative HPLC; purpuroine K-M. These compounds where screened for antibacterial- and antifungal activity, antibiofilm formation ...
    • Identification of New Purpuroine Analogues from the Arctic Echinodermata Pteraster militaris That Inhibit FLT3-ITD+ AML Cell Lines 

      Ullsten-Wahlund, Sara; Petit, Guillaume; Isaksson, Johan Mattias; Hansen, Ida Kristine Østnes; Schneider, Yannik Karl Heinz; Jenssen, Marte; Li, Chun; Østnes Hansen, Kine (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-13)
      Isolation of bioactive products from the marine environment is considered a very promising approach to identify new compounds that can be used for further drug development. In this work we have isolated three new compounds from the purpuroine family by mass-guided preparative HPLC; purpuroine K-M. These compounds where screened for antibacterial- and antifungal activity, antibiofilm formation and ...
    • Lulworthinone, a New Dimeric Naphthopyrone From a Marine Fungus in the Family Lulworthiaceae With Antibacterial Activity Against Clinical Methicillin-Resistant Staphylococcus aureus Isolates 

      Jenssen, Marte; Rainsford, Philip; Juskewitz, Eric; Andersen, Jeanette Hammer; Hansen, Espen; Isaksson, Johan; Rämä, Teppo; Østnes Hansen, Kine (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-01)
      The emergence of drug-resistant bacteria is increasing rapidly in all parts of the world, and the need for new antibiotics is urgent. In our continuous search for new antimicrobial molecules from under-investigated Arctic marine microorganisms, a marine fungus belonging to the family Lulworthiaceae (Lulworthiales, Sordariomycetes, and Ascomycota) was studied. The fungus was isolated from driftwood, ...
    • Lulworthinone: In Vitro Mode of Action Investigation of an Antibacterial Dimeric Naphthopyrone Isolated from a Marine Fungus 

      Juskewitz, Eric; Mishchenko, Ekaterina; Dubey, Vishesh Kumar; Jenssen, Marte; Jakubec, Martin; Rainsford, Philip; Isaksson, Johan Mattias; Andersen, Jeanette Hammer; Ericson, Johanna U (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-21)
      Treatment options for infections caused by antimicrobial-resistant bacteria are rendered ineffective, and drug alternatives are needed—either from new chemical classes or drugs with new modes of action. Historically, natural products have been important contributors to drug discovery. In a recent study, the dimeric naphthopyrone lulworthinone produced by an obligate marine fungus in the family ...
    • Two Novel Lyso-Ornithine Lipids Isolated from an Arctic Marine Lacinutrix sp. Bacterium 

      Kristoffersen, Venke; Jenssen, Marte; Raid Jawad, Heba; Isaksson, Johan; Hansen, Espen; Rämä, Teppo; Østnes Hansen, Kine; Andersen, Jeanette Hammer (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-31)
      The Lacinutrix genus was discovered in 2005 and includes 12 Gram-negative bacterial species. To the best of our knowledge, the secondary metabolite production potential of this genus has not been explored before, and examination of Lacinutrix species may reveal novel chemistry. As part of a screening project of Arctic marine bacteria, the Lacinutrix sp. strain M09B143 was cultivated, extracted, ...